B.I. Stepanov Institute of Physics

http://ifan.basnet.by/  
220072 Minsk, Nezavisimosti ave. 68/2

Manufacture and supply of singlet oxygen laser dosimeters in biological tissues

COUNTRY OF ORIGIN

IDENTIFIER

BO4413

PUBLISHED

2021-11-02

LAST UPDATE

2024-01-24

DEADLINE

Linked profile in other language
Responsible
Denis Shabrov
+375 17 284 2341
onti@ifanbel.bas-net.by
Summary
B.I.Stepanov Institute of Physics of the National Academy of Sciences of Belarus offers consumers singlet oxygen laser dosimeters in biological tissues under a manufacturing agreement and is looking for partners interested in a distribution services agreement.
Description
B.I.Stepanov Institute of Physics of the National Academy of Sciences of Belarus manufactures laser dosimeters designed to study the photochemical processes of singlet oxygen in vivo occurring in biological tissues and cell cultures during photodynamic therapy.

The laser dosimeter is designed to register ultra-weak photosensitized luminescence of singlet oxygen of nano- and microsecond duration in the near-IR range of the spectrum (1200..1350 nm).

The original optical scheme provides a unique opportunity to study the time evolution of the luminescence signals of singlet oxygen fr om the tissue surface of experimental animals without placing the objects of study in a light-insulated chamber.

With the help of the created dosimeter, the characteristics of the luminescence of singlet oxygen in various media were determined, the luminescence of singlet oxygen from the surface of the tissue treated with Photolon (R) ointment, intended for the treatment of tumor neoplasms by the method of photodynamic therapy, was recorded.

The laser dosimeter has specialized software for operation control, accumulation, data processing and subsequent construction of a spectral-temporal pattern of luminescence.

Specifications:
Radiation wavelengths, nm 532,667
Registration wavelengths, nm 1200, 1250, 1275, 1300, 1350
Minimal detectable quantum yield of luminescence
of singlet oxygen, arb. un.
10-9
Operation mode, kHz pulsed, 1..10
Power supply, V/Hz ~ 100..240/50..60
Power consumption, kW ≤ 1,0
Experimental table area for placing sample irradiation
units and light radiation registration, m2
1x0,8
Overall weight without control PC, kg ≤ 30

Areas of application:
* experimental photomedicine;
* molecular biophysics;
* solid state physics and other areas of science and technology wh ere there is a need to register the ultra-weak glow of singlet oxygen in the near-IR spectral range.

B.I.Stepanov Institute of Physics offers partners:
* singlet oxygen laser dosimeters in biological tissues under a manufacturing agreement;
* singlet oxygen laser dosimeters in biological tissues under a distribution services agreement.

Catalogue of developments & services of «B.I. Stepanov Institute of Physics» 2022, p.48.

Link on the B.I.Stepanov Institute of Physics site.
Advantages and Innovations
The singlet oxygen laser dosimeter provides record-breaking detection sensitivity from the surface of the studied samples of all shapes and sizes without placing the latter in a light-insulated chamber. There are no similar in vivo singlet oxygen dosimeters in the CIS and abroad.

The laser dosimeter will allow monitoring the process of the appearance and disappearance of singlet oxygen in vivo during a photodynamic therapy session and increase the effectiveness of this treatment method by optimizing the light regime.
Stage of development
Field tested/evaluated (TRL8)
Funding source
State budged
Internal
IPR status
Exclusive rights
Secret know-how
Sector group
Healthcare

Organization information

Type
R&D institution
Year established
1955
NACE keywords
C.32.99 - Other manufacturing n.e.c.
M.72.19 - Other research and experimental development on natural sciences and engineering
M.74.90 - Other professional, scientific and technical activities n.e.c.
Turnover (in EUR)
10-20M
Already engaged in transnational cooperation
Yes
Additional comments
The directions of scientific research and development of the B.I.Stepanov Institute of Physics are currently:
* Laser physics, development and creation of laser systems and technologies for medicine, ecology, industry, metrology and information protection;
* Physical and nonlinear optics, the disclosure and use of the patterns of propagation of high-power laser radiation in various media;
* Optical spectroscopy, development and application of methods and instruments for studying the properties and structure of various materials, including biotissues;
* Nanooptics and Nanomaterials;
* Quantum optics, investigation of quantum properties of electromagnetic radiation in computer science and cryptography;
* Investigation of the structure and properties of atomic-molecular structures and the creation of new optical materials, systems, instruments and technologies on this base;
* Plasma physics and plasma technologies: investigation of the plasma interaction with fields and matter; development and application of methods for plasma diagnostics, development of technological applications of gas-discharge and laser plasma
* Micro- and optoelectronics: LED technology, solar cells, microwave technology, microelectromechanical and sensor systems and devices;
* Physics of Fundamental Interactions and Nuclear Reactions - Investigating the Structure of the Microcosm and the Universe.

The B.I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus has scientific contacts with many countries. At present, more than 50 agreements on scientific and technical cooperation have been signed with organizations from 15 countries.

The Institute develops, manufactures and supplies laser and optical instruments for various purposes, as well as innovative components for laser technology, to many countries of the world (Russia, China, Germany, France, the United States, Saudi Arabia, India, etc.).
Languages spoken
English
Russian

Information about partnership

Type of partnership considered
Distribution services agreement
Manufacturing agreement
Type and role of partner sought
Consumers interested in purchasing singlet oxygen laser dosimeters in biological tissues under a manufacturing agreement.

Partners interested in purchasing singlet oxygen laser dosimeters in biological tissues under a distribution services agreement.
Type and size of partner sought
251-500
SME 51-250
SME 11-50
SME <= 10
R&D Institution
University

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