Institute of Biochemistry of Biologically Active Compounds

https://ibiochemistry.by/  
230030 Grodno, A. Tyzengauz Square, 7

Hepatoprotective agent based on berberine and silymarin in a self-emulsifying delivery system

COUNTRY OF ORIGIN

IDENTIFIER

BO4841

PUBLISHED

2022-03-03

LAST UPDATE

2022-03-06

DEADLINE

Linked profile in other language
Responsible
Summary
The Institute of Biochemistry of Bioactive Compounds offers consumers a hepatoprotective agent containing berberine and silymarin in a self-emulsifying delivery system under a manufacturing agreement, offers services for the development of methods for the use of a hepatoprotective agent under an outsourcing agreement, and is looking for partners interested in a distribution service agreement.
Description
A product based on milk thistle flavonoids and berberine in a self-emulsifying delivery system has been developed; studies indicate a high hepatoprotective, anti-inflammatory and anti-fibrotic activity of the combination of milk thistle flavonoids (silymarin) and berberine as part of the developed self-emulsifying delivery system.
Advantages and Innovations
An increase in the bioavailability of berberine and silymarin in the composition of the developed self-emulsifying delivery system was shown compared to their use in a free form; a pronounced hepatoprotective effect of the combination of these flavonoids was found in acute and subchronic liver damage with carbon tetrachloride and acute damage with toxic doses of acetaminophen, superior to the effect of silymarin and berberine and a combination of drugs in free form.
Stage of development
Field tested/evaluated (TRL8)
Funding source
State budged
Internal
IPR status
Exclusive rights
Secret know-how
Sector group
BioChemTech
Environment

Organization information

Type
R&D institution
Year established
1970
NACE keywords
Q.86.90 - Other human health activities
M.72.11 - Research and experimental development on biotechnology
M.72.19 - Other research and experimental development on natural sciences and engineering
M.74.90 - Other professional, scientific and technical activities n.e.c.
Turnover (in EUR)
1-10M
Already engaged in transnational cooperation
Yes
Additional comments
In the structural subdivisions of the institute, research is carried out in the field of vitaminology, the study of molecular mechanisms of regulation of metabolism in normal and pathological conditions, the biochemistry of alcohol and drug addiction, neurochemistry and pharmacology.

The main activities are as follows: conducting fundamental and applied research aimed at studying the mechanisms of pathogenesis of diseases of the liver, cardiovascular and endocrine systems, alcohol dependence, pathological conditions associated with a deficiency of essential micronutrients and the effects of stress, in order to develop methods for their prevention, diagnosis and therapy; development of new innovative medicines, vitamin preparations, dietary supplements, as well as the development of methods for the isolation and purification of biologically active compounds from herbal medicinal raw materials, the development of their laboratory production for the needs of the pharmaceutical industry.

The Institute has developed unique technologies for obtaining dry extracts from medicinal plant materials and spicy-aromatic plants for use as components:
- in the production of dietary supplements,
- in the food industry,
- in the production of perfumery.

Production under the order of products of deep processing and purification of extracts from vegetable raw materials for use as analytical standards is possible.
Languages spoken
English
Russian

Information about partnership

Type of partnership considered
Distribution services agreement
Manufacturing agreement
Outsourcing agreement
Type and role of partner sought
Consumers interested in purchasing a hepatoprotective product containing berberine and silymarin in a self-emulsifying delivery system under a manufacturing agreement.

Consumers interested in services for the development of methods for the use of a hepatoprotective agent under an outsourcing agreement.

Distributors, interested in purchasing a hepatoprotective product containing berberine and silymarin in a self-emulsifying delivery system under a distribution service agreement.
Type and size of partner sought
251-500
SME 51-250
SME 11-50
SME <= 10
R&D Institution
University

Attachments

Views: 1114
Statistics since 03.03.2022 16:45:43