Institute of Physiology  
220072 Minsk, Academic St., 28

Neurogistochemical express diagnostics of Hirschsprung's disease in children









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Tatiana Khrustaleva
+375 17 378 1630
The Institute of Physiology offers consumers a method of neurohistochemical rapid diagnostics of Hirschsprung's disease in children under a commercial agreement with technical assistance and is looking for partners to conclude an research cooperation agreement.
A method for determining the fibers of the parasympathetic nervous system in biopsy material by the histochemical method has been developed and introduced into clinical practice. Analysis of the state of the parasympathetic intramural nervous apparatus of the rectal mucosa contributes to the early and effective diagnosis of Hirschsprung's disease in children.
Advantages and Innovations
Determination of the density of distribution of cholinergic fibers in the wall of the colon is the basis for the development of recommendations on the level of resection of the intestine in patients with surgical treatment.
Stage of development
Field tested/evaluated (TRL8)
Funding source
State budged
IPR status
Exclusive rights
Secret know-how
Sector group

Organization information

R&D institution
Year established
NACE keywords
Q.86.90 - Other human health activities
M.72.11 - Research and experimental development on biotechnology
M.72.19 - Other research and experimental development on natural sciences and engineering
M.74.90 - Other professional, scientific and technical activities n.e.c.
Turnover (in EUR)
Already engaged in transnational cooperation
Additional comments
The Institute is a leading scientific institution coordinating physiological research in the Republic of Belarus. The institute successfully carries out fundamental and applied research aimed at developing methods for the prevention and correction of pathological conditions of hypoxic, ischemic and inflammatory origin, and develops new devices and methods for their therapeutic and prophylactic use. The main scientific activity of the divisions is currently focused on studying the mechanisms of the formation of pathological conditions of the body (primarily hypoxic and neurodestructive) and substantiating new technologies for prevention, treatment and rehabilitation. Particular attention is paid to the development of complex methods for the treatment of malignant tumors using effectors of the blockade of metabolism and high-intensity pulsed magnetic fields and methods for controlling the proliferation of tumor cells based on changes in the functional state of neuroreceptors in vitro and in vivo, as well as the development of a method for immunotherapy of patients suffering from pancreatic cancer. , using autologous dendritic cells primed with tumor antigens and elucidating new mechanisms of tumor formation, substantiation of prevention methods. Research is underway on the molecular mechanisms of proliferation, differentiation, and oncogenesis; physiological and therapeutic effect of physical factors and the development of new technologies of physiotherapy and physiotherapy equipment and experimental analysis of the positive and negative aspects of the use of nanoparticles and heterocyclic compounds in biomedical technologies. The neurophysiological bases of dysregulation of the functions of internal organs during ischemia of the nervous tissue of various origins are being studied. Works on the physiology of nutrition and sports are being carried out. Preclinical studies of drugs and nanomaterials are underway.
Languages spoken

Information about partnership

Type of partnership considered
Commercial agreement with technical assistance
Research cooperation agreement
Type and role of partner sought
Consumers interested in purchasing the method of neurohistochemical express diagnostics of Hirschsprung's disease in children under a commercial agreement with technical assistance.

Partners interested in concluding an research cooperation agreement.
Type and size of partner sought
SME 51-250
SME 11-50
SME <= 10
R&D Institution
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Statistics since 12.03.2022 10:51:54