Institute of Biochemistry of Biologically Active Compounds

https://ibiochemistry.by/  
230030 Grodno, A. Tyzengauz Square, 7

A new factor regulating the development of fibrosis in the liver (iecur)

COUNTRY OF ORIGIN

IDENTIFIER

TO4840

PUBLISHED

2022-03-03

LAST UPDATE

2022-03-06

DEADLINE

Linked profile in other language
Responsible
Summary
The Institute of Biochemistry of Biologically Active Compounds offers consumers a technology that regulates the processes of fibrogenesis in fibrosis, cirrhosis of the liver under a commercial agreement with technical assistance and is looking for partners to conclude an agreement on scientific cooperation.
Description
A new factor has been discovered that regulates the processes of fibrogenesis in fibrosis, cirrhosis of the liver (iecur). Pituitary tumor-transforming tumor-transforming (PTTG) gene knockout and normal mice were induced with hepatic fibrosis by administration of thioacetamide. Histological and biochemical signs of fibrosis were significantly less pronounced in animals lacking PTTG. The mRNA expression of the TNFα, TGFβ, and VEGF signaling molecules was also significantly lower in mice lacking PTTG. The data obtained indicate an important regulatory role of the gene transforming pituitary tumors in the progression of liver (iecur) fibrosis.
Advantages and Innovations
PTTG should be considered as an important new target for pharmacotherapy for the prevention and treatment of liver (iecur) fibrosis and cirrhosis. The search for PTTG inhibitors may open a new era in the treatment of this pathology.
Stage of development
Under development/lab tested (TRL4)
Funding source
State budged
Internal
IPR status
Exclusive rights
Secret know-how
Sector group
BioChemTech
Healthcare

Organization information

Type
R&D institution
Year established
1970
NACE keywords
Q.86.90 - Other human health activities
M.72.11 - Research and experimental development on biotechnology
M.72.19 - Other research and experimental development on natural sciences and engineering
M.74.90 - Other professional, scientific and technical activities n.e.c.
Turnover (in EUR)
1-10M
Already engaged in transnational cooperation
Yes
Additional comments
In the structural subdivisions of the institute, research is carried out in the field of vitaminology, the study of molecular mechanisms of regulation of metabolism in normal and pathological conditions, the biochemistry of alcohol and drug addiction, neurochemistry and pharmacology.

The main activities are as follows: conducting fundamental and applied research aimed at studying the mechanisms of pathogenesis of diseases of the liver, cardiovascular and endocrine systems, alcohol dependence, pathological conditions associated with a deficiency of essential micronutrients and the effects of stress, in order to develop methods for their prevention, diagnosis and therapy; development of new innovative medicines, vitamin preparations, dietary supplements, as well as the development of methods for the isolation and purification of biologically active compounds from herbal medicinal raw materials, the development of their laboratory production for the needs of the pharmaceutical industry.

The Institute has developed unique technologies for obtaining dry extracts from medicinal plant materials and spicy-aromatic plants for use as components:
- in the production of dietary supplements,
- in the food industry,
- in the production of perfumery.

Production under the order of products of deep processing and purification of extracts from vegetable raw materials for use as analytical standards is possible.
Languages spoken
English
Russian

Information about partnership

Type of partnership considered
Commercial agreement with technical assistance
Research cooperation agreement
Type and role of partner sought
Consumers interested in purchasing technology that regulates fibrogenesis processes in fibrosis, cirrhosis of the liver under a commercial agreement with technical assistance.

Partners interested in concluding an research cooperation agreement.
Type and size of partner sought
251-500
SME 51-250
SME 11-50
SME <= 10
R&D Institution
University

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