The Institute of Chemistry of New Materials offers nanocatalysts based on halloysite nanotubes for stereoselective production of biologically active heterocyclic compounds (octahydro-2H-chromene-4-ols) from natural terpenoids (isopulegol) and their production technology. The Institute is looking for partners to conclude a license agreement and a commercial agreement with technical support.

New nanocatalysts based on halloysite nanotubes for stereoselective production of biologically active heterocyclic compounds (octahydro-2H-chromene-4-ols) from natural terpenoids (isopulegol).
High reactivity and multivariance of terpene conversions lead to the formation of complex reaction mixtures with low yields of target products. An increase in the yield can be achieved through the use of highly selective catalysts. It has been established that natural halloysite nanotubes are a promising basis for the creation of new catalytic systems for the synthesis of heterocyclic compounds. The use of nanocatalytic systems based on halloysite nanotubes opens up broad prospects for the stereoselective synthesis of physiologically active heterocyclic compounds based on monoterpenoids.
A method has been developed for directed chemical and thermal modification of natural halloysite nanotubes, which makes it possible to create on its surface catalytically active regions of Lewis and Bronsted nature with a certain concentration and acidic strength. A mechanism has been proposed for the specific catalytic action of nanotubes, which ensures the formation of an intermediate of a certain structure and the transfer of water molecules from the surface of nanotubes to this compound, leading to the formation of the 4R-stereoisomer.

It was found that the selectivity of the reaction of isopulegol terpenoid with aldehydes in octahydro-2H-chromene-4-olam reaches 94.2%, which is significantly higher than on other catalytic systems. The yield of the individual 4R ‑ isomer of thiophenyl-substituted chromenol with a high analgesic effect is 80%, which is significantly higher than with the imported catalyst K ‑ 10 (64%).

The Institute conducts research in broad international scientific cooperation with research centers in Russia, Azerbaijan, China, Vietnam, Saudi Arabia, the USA, Poland, Germany, Italy, Israel, the Republic of Korea, regularly holds International conferences on the problems of obtaining high-tech low-tonnage chemical products for various functional purposes, as well as alternative sources of raw materials and fuels.

Consumers interested in purchasing a technology for producing nanocatalysts based on halloysite nanotubes for stereoselective production of biologically active heterocyclic compounds (octahydro-2H-chromene-4-ols) from natural terpenoids (isopulegol) and their production technology. to conclude a license agreement and a commercial agreement with technical support.