The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus offers consumers environmentally friendly products based on the natural phytohormone epibrassinolide, which increase plant resistance to stress, under a manufacturing agreement and is looking for partners to conclude a distribution dervices agreement.

Plant growth and development stimulants based on epibrassinolide, a natural phytohormone, are widely used in agriculture to increase crop yields, resistance to stress factors (drought, frost, disease), and improve product quality. Epibrassinolide is one of the most effective brassinosteroids for stimulating plant growth.

Major global manufacturers of epibrassinolide-based growth stimulants:

1. Valent Biosciences (USA)
- Features: The company specializes in the production of biostimulants and plant growth regulators, including brassinosteroid-based products.
2. Jiangsu Fengyuan Bioengineering Co., Ltd. (China)
- Features: Manufacturer of biostimulants, including epibrassinolide, for agriculture.
3. BASF SE (Germany)
- Features: Manufacturer of biostimulants and plant growth regulators, including solutions based on natural phytohormones.
4. Horizont Agrotech (India)
- Features: The company offers biostimulants and plant growth regulators, including products based on brassinosteroids.
5. Syngenta AG (Switzerland)
- Features: One of the world's largest producers of agrochemicals, including plant growth stimulants.

The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus offers the plant growth and development stimulants "Epin" and "Epin Plus" based on the natural phytohormone epibrassinolide.
These products are effective immunomodulators that increase plant resistance to stress (disease and pests, extreme temperatures, drought or waterlogging, and soil salinity).

"Epin" and "Epin Plus" are safe for humans, mammals, insects, and fish. They have a shelf life of 5 years.
Scope: agriculture, private farms.

Recommended for use on vegetable crops, legumes, potatoes, fruit and berry crops, flowers and ornamental plants, industrial crops, and forage crops.
Approved for use in the agro-industrial complex and on private farms. TU BY 100185129.048. It can be applied by treating plants or seeds, as well as in mineral fertilizers, using standard equipment and existing technologies.

Recommendations for the use of Epin can be found on the website of the Institute of Bioorganic Chemistry.

The distinctive features of these preparations include:
* low effective doses, comparable to the natural hormone content of plants (from 5 to 50 mg/ha);
* ensuring a high survival rate of seedlings when transplanted and planted in their permanent location; frozen and wilted plants are restored to life;
* reduced maturation time;
* reduced accumulation of nitrates, radionuclides, and heavy metal salts.

The drug is included in the “State Register of Plant Protection Products and Fertilizers Permitted for Use in the Republic of Belarus” (Certificate No. 4390 on state registration of plant protection products dated January 24, 2020, state registration number 10-0022).

Currently, the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus is the leading research center in the Republic of Belarus and one of the most renowned international centers for the study of key biopolymers (proteins, enzymes, nucleic acids) and low-molecular-weight bioregulators (human, insect, and plant steroid hormones, peptides, phospholipids, prostaglandins, and their synthetic analogs).

Main areas of activity:
- Fundamental and applied research in the chemistry, structure, and function of biopolymers and low-molecular-weight bioregulators, including proteins, nucleic acids and their components, phospholipids, steroids, prostaglandins, brassinosteroids, and ecdysteroids;
- Development and pilot production of immunochemical and molecular biological reagent kits for medical and veterinary diagnostics;
- Development and production of pharmaceutical substances, hormonal preparations, and biospecific hemosorbents;
- Development of technologies for the production and use of growth stimulants and plant protection products;
- Experimental and clinical pharmacology, pharmacy and drug technology, toxicology, human and animal biochemistry, biomedical and pharmaceutical chemistry;
- Preclinical, bioequivalence, and pharmaceutical testing.

Main research areas:
- Organic and bioorganic chemistry of low-molecular-weight bioregulators (steroids, peptides, prostaglandins, lipids, nucleosides, and nucleotides) and key biopolymers, including proteins and nucleic acids, and the elucidation of their functioning in living systems;
- Development of new chemical, chemical-enzymatic, and genetic engineering methods for producing biopolymers and low-molecular-weight bioregulators and their analogs for the development of pharmaceuticals for medicine and agriculture;
- Study of the structure, physicochemical properties, and biological activity of natural biomolecules and their analogs, establishing the relationship between their structure and biological activity, and developing scientific principles for the targeted search for substances with predictable biological activity. - study of the structure, function, and mechanism of action of enzyme systems involved in the biosynthesis and metabolism of key natural bioregulators and xenobiotics;
- development of technologies for the production of reagents for medical diagnostics, pharmaceuticals, and plant protection chemicals.

The institute has experimental facilities for studying the biological activity of the resulting compounds at the cellular level and in animal models. Five pilot production sites have been established at the institute for pilot production of the developed products (hemosorbents, recombinant enzyme preparations, immunochemical reagents, oxyphytosterols, etc.).

The results of fundamental and applied research on methods and means for protecting plants from diseases, insects, weeds, and other adverse environmental factors that are safe for humans and the biosphere as a whole have formed the foundation for the development of new plant growth stimulants, pheromone compositions (codling moth LP-U and miller moth pheromones), active pesticide ingredients, and pesticide formulations (herbicides, insecticides, fungicides, etc.).

The institute's intellectual property currently consists of valid patents, laboratory process and pilot industrial regulations, technical specifications, and trademarks. License agreements are in place for the transfer of technologies for the production of immunodiagnostic products, hemosorbents, and pesticides to manufacturers.

The Institute of Bioorganic Chemistry is successfully developing international ties in its core research areas. The institute currently conducts joint research with research institutes in the CIS countries, Germany, the USA, Canada, Sweden, Finland, Denmark, the Netherlands, Vietnam, and other countries.

Official website of the Institute of Bioorganic Chemistry.