The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus offers consumers a kit for the affinity sorption of macromolecules on magnetic particles under a manufacturing agreement and is looking for partners to conclude a distribution dervices agreement.

Kits for creating conjugates of antibodies, proteins, or other macromolecules with magnetic microspheres are widely used in biomedical research, diagnostics, and biotechnology. They are used for immunoaffinity purification, magnetic separation, disease diagnostics, and other applications.

The world's largest manufacturers of medical kits for creating conjugates with magnetic microspheres are Thermo Fisher Scientific, Miltenyi Biotec, Bio-Rad Laboratories, Merck KGaA (Sigma-Aldrich), and Dynabeads (Thermo Fisher). These companies offer reliable and efficient solutions for biomedical research and diagnostics.

1. Thermo Fisher Scientific (USA)
- Features: One of the largest manufacturers of biotechnology research kits, including magnetic microspheres and conjugation reagents.
2. Miltenyi Biotec (Germany)
- Official website: (https://www.miltenyibiotec.com/)
- Key Features: The company specializes in magnetic technologies, offering kits for conjugating antibodies to microspheres for cell separation and analysis.
3. Bio-Rad Laboratories (USA)
- Key Features: Manufacturer of products for biotechnology and medical research, including magnetic microspheres and kits for their modification.
4. Merck KGaA (Sigma-Aldrich, Germany)
- Key Features: The company offers a wide range of magnetic microspheres and reagents for creating conjugates with proteins and antibodies.
5. Dynabeads (a division of Thermo Fisher Scientific, USA)
- Key Features: A leader in the production of magnetic microspheres (Dynabeads) and kits for their functionalization and conjugation.

A kit developed at the Institute of Bioorganic Chemistry is designed to create conjugates of antibodies (proteins or other macromolecules) with magnetic microspheres. The kit contains 200 µl of magnetic microspheres at a concentration of 50 mg/ml, capable of binding up to 100 µg of antibodies, which is comparable to similar commercially available particles.

The protocol is designed to last 8 hours and requires specialized equipment and materials. It uses an enzyme-linked immunosorbent assay (ELISA) to assess binding.

Currently, the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus is the leading research center in the Republic of Belarus and one of the most renowned international centers for the study of key biopolymers (proteins, enzymes, nucleic acids) and low-molecular-weight bioregulators (human, insect, and plant steroid hormones, peptides, phospholipids, prostaglandins, and their synthetic analogs).

Main areas of activity:
- Fundamental and applied research in the chemistry, structure, and function of biopolymers and low-molecular-weight bioregulators, including proteins, nucleic acids and their components, phospholipids, steroids, prostaglandins, brassinosteroids, and ecdysteroids;
- Development and pilot production of immunochemical and molecular biological reagent kits for medical and veterinary diagnostics;
- Development and production of pharmaceutical substances, hormonal preparations, and biospecific hemosorbents;
- Development of technologies for the production and use of growth stimulants and plant protection products;
- Experimental and clinical pharmacology, pharmacy and drug technology, toxicology, human and animal biochemistry, biomedical and pharmaceutical chemistry;
- Preclinical, bioequivalence, and pharmaceutical testing.

Main research areas:
- Organic and bioorganic chemistry of low-molecular-weight bioregulators (steroids, peptides, prostaglandins, lipids, nucleosides, and nucleotides) and key biopolymers, including proteins and nucleic acids, and the elucidation of their functioning in living systems;
- Development of new chemical, chemical-enzymatic, and genetic engineering methods for producing biopolymers and low-molecular-weight bioregulators and their analogs for the development of pharmaceuticals for medicine and agriculture;
- Study of the structure, physicochemical properties, and biological activity of natural biomolecules and their analogs, establishing the relationship between their structure and biological activity, and developing scientific principles for the targeted search for substances with predictable biological activity. - study of the structure, function, and mechanism of action of enzyme systems involved in the biosynthesis and metabolism of key natural bioregulators and xenobiotics;
- development of technologies for the production of reagents for medical diagnostics, pharmaceuticals, and plant protection chemicals.

The institute has experimental facilities for studying the biological activity of the resulting compounds at the cellular level and in animal models. Five pilot production sites have been established at the institute for pilot production of the developed products (hemosorbents, recombinant enzyme preparations, immunochemical reagents, oxyphytosterols, etc.).

The results of fundamental and applied research on methods and means for protecting plants from diseases, insects, weeds, and other adverse environmental factors that are safe for humans and the biosphere as a whole have formed the foundation for the development of new plant growth stimulants, pheromone compositions (codling moth LP-U and miller moth pheromones), active pesticide ingredients, and pesticide formulations (herbicides, insecticides, fungicides, etc.).

The institute's intellectual property currently consists of valid patents, laboratory process and pilot industrial regulations, technical specifications, and trademarks. License agreements are in place for the transfer of technologies for the production of immunodiagnostic products, hemosorbents, and pesticides to manufacturers.

The Institute of Bioorganic Chemistry is successfully developing international ties in its core research areas. The institute currently conducts joint research with research institutes in the CIS countries, Germany, the USA, Canada, Sweden, Finland, Denmark, the Netherlands, Vietnam, and other countries.

Official website of the Institute of Bioorganic Chemistry.