Scientific and Practical Centre for Animal Husbandry
http://belniig.by/

Milk with high human lactoferrin (hLF) content from genetically altered goats

COUNTRY OF ORIGIN

Belarus

IDENTIFIER

BO4044

PUBLISHED

2021-07-09

LAST UPDATE

2021-10-07

DEADLINE

Linked profile in other language
Responsible
Alexander Budzevich
+375 29 346 9148
budevich7388100@mail.ru
Summary
Belarusian research organization offers milk with high lactoferrin content from genetically altered goats to obtain recombinant human lactoferrin (rhLF) protein for nutritional and therapeutic applications and for further investigation into its mechanism of action under manufacturing agreement, distribution services agreement or joint venture agreement.
Description
Lactoferrin (LF) is a metal binding glycoprotein found in milk of various mammalian species, including humans, bovines, cows, goats, horses, etc. Colostrum, the first milk produced after a baby is born, is high in lactoferrin content (up to 9,8 g/l). The biological functions proposed for LF include protection against microbial infection, enhanced intestinal iron absorption, promotion of cell growth, regulation of myelopoiesis and modulation of inflammatory responses.
However, production of LF is severely limited by the available amount of human milk, the major source of native human lactoferrin (nhLF). Recombinant lactoferrin (rLF) or recombinant human lactoferrin (rhLF) can be made by recombinant expression or direct production in genetically altered animals, plants, fungi, bacteria or through chemical synthesis.
On the world market there is no efficient and economical way to produce human LF (hLF). Instead lactoferrin from bovine milk (bLF) has been approved by the authorities as a dietary supplement, but bLF amino acids are only 67% identical to hLF, which limits its therapeutic efficiency.

Belarusian research organization offers milk with high lactoferrin content from genetically altered goats. The milk can be purified to obtain recombinant human lactoferrin (rhLF), for example, by cation-exchange chromatography, or to produce lactoserum.

Obtained rhLF is identical to native human LF and can be used:
* as a dietary supplement or
* in medicine, as it shows antimicrobial, antinflammatory, antiparasitic, antifugal, anticancer properties and lately a potential for the treatment and prevention of COVID-19.

Belarusian organization:
* offers milk in frozen or liquid state to industrial partners or research institutions under manufacturing agreement;
* offers milk in frozen state to industrial partners under distribution services agreement;
* propose joint venture agreement to industrial partners with the goal to up-scale milk production. The Belarusian organization's investment is flock of genetically altered goats.
Advantages and Innovations
Milk from genetically altered goats:
* contain 2-5 g/l of human LF, compared to 0,03-0,49 g/l LF in bovine milk;
* obtained recombinant human LF is identical to native human LF;
* goat milk can be produced in sufficient quantity;
* the price of rhLF can be 400 times cheaper than nhLH;
* up-scaling the production will create world market for widely available LF-based products;
* goat milk can be delivered in a frozen, liquid, or powder state.
Stage of development
Already on the market
Funding source
State budged
Internal
IPR status
Exclusive rights
Secret know-how
Sector group
Agrofood
BioChemTech
Healthcare

Organization information

Year established
1949
NACE keywords
A.01.45 - Raising of sheep and goats
M.72.11 - Research and experimental development on biotechnology
Turnover (in EUR)
1-10M
Already engaged in transnational cooperation
Yes
Languages spoken
English
Russian

Information about partnership

Type of partnership considered
Distribution services agreement
Joint venture agreement
Manufacturing agreement
Type and role of partner sought
Belarusian organization:
* offers milk in frozen, liquid, or powder state to industrial partners producing dietary supplements or research institutions performing studies of rhLF properties/applications under manufacturing agreement;
* offers milk in frozen or powder state to industrial partners under distribution services agreement;
* propose joint venture agreement to industrial partners. The partner's role is to provide sales and financial contribution to up-scaling milk production.
Type and size of partner sought
> 500 MNE
> 500
251-500
SME 51-250
SME 11-50
SME <= 10
R&D Institution

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Статистика ведется с 09.07.2021 15:17:05