The Institute of Bioorganic Chemistry offers consumers the biospecific hemosorbent "IgG-hemosorb" for the selective removal of immunoglobulins of class G by extracorporeal detoxification under a manufacturing agreement and is looking for partners to conclude a distribution services agreement.

Biospecific hemosorbents for the selective removal of immunoglobulin G (IgG) are used in extracorporeal detoxification for the treatment of autoimmune diseases, the prevention of transplant rejection, and other medical conditions. These devices and materials are used in hemosorption and therapeutic apheresis.

Major global manufacturers of biospecific hemosorbents for IgG removal:

1. Fresenius Medical Care (Germany)
- Features: One of the largest manufacturers of equipment and consumables for extracorporeal therapy, including hemosorbents for immunoglobulin removal.
2. Asahi Kasei Medical Co., Ltd. (Japan)
- Features: Manufacturer of extracorporeal detoxification systems, including hemosorption materials for IgG removal.
3. Jafron Biomedical Co., Ltd. (China)
- Features: One of the leaders in the production of hemosorbents for extracorporeal detoxification, including products for IgG removal.
4. CytoSorbents Corporation (USA)
- Features: Manufacturer of hemosorption columns, including specialized products for immunoglobulin removal.
5. Medtronic (USA)
- Features: The company develops technologies for extracorporeal detoxification, including sorbents for specific protein removal.

The biospecific hemosorbent "IgG-Hemosorb," developed at the Institute of Bioorganic Chemistry, is a polymer containing a polyacrylamide gel with a peptide ligand, packaged in a mass-exchange module for single-use hemosorption. The hemosorbent is designed for the selective removal of immunoglobulin G (IgG) through extracorporeal detoxification in the treatment of diseases associated with elevated IgG levels in the blood.

Information about hemosorbents is available on the official website of the Institute of Bioorganic Chemistry in the "Developments of the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus" section.

Currently, there are no similar imported hemosorbents registered in the Republic of Belarus.
The sorption capacity of the IgG-Hemosorb hemosorbent for immunoglobulin G is 0.7 mg IgG per 1 g of gel, compared to 1.2 mg/ml for the best foreign product, Immunosorba.

Currently, the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus is the leading research center in the Republic of Belarus and one of the most renowned international centers for the study of key biopolymers (proteins, enzymes, nucleic acids) and low-molecular-weight bioregulators (human, insect, and plant steroid hormones, peptides, phospholipids, prostaglandins, and their synthetic analogs).

Main areas of activity:
- Fundamental and applied research in the chemistry, structure, and function of biopolymers and low-molecular-weight bioregulators, including proteins, nucleic acids and their components, phospholipids, steroids, prostaglandins, brassinosteroids, and ecdysteroids;
- Development and pilot production of immunochemical and molecular biological reagent kits for medical and veterinary diagnostics;
- Development and production of pharmaceutical substances, hormonal preparations, and biospecific hemosorbents;
- Development of technologies for the production and use of growth stimulants and plant protection products;
- Experimental and clinical pharmacology, pharmacy and drug technology, toxicology, human and animal biochemistry, biomedical and pharmaceutical chemistry;
- Preclinical, bioequivalence, and pharmaceutical testing.

Main research areas:
- Organic and bioorganic chemistry of low-molecular-weight bioregulators (steroids, peptides, prostaglandins, lipids, nucleosides, and nucleotides) and key biopolymers, including proteins and nucleic acids, and the elucidation of their functioning in living systems;
- Development of new chemical, chemical-enzymatic, and genetic engineering methods for producing biopolymers and low-molecular-weight bioregulators and their analogs for the development of pharmaceuticals for medicine and agriculture;
- Study of the structure, physicochemical properties, and biological activity of natural biomolecules and their analogs, establishing the relationship between their structure and biological activity, and developing scientific principles for the targeted search for substances with predictable biological activity. - study of the structure, function, and mechanism of action of enzyme systems involved in the biosynthesis and metabolism of key natural bioregulators and xenobiotics;
- development of technologies for the production of reagents for medical diagnostics, pharmaceuticals, and plant protection chemicals.

The institute has experimental facilities for studying the biological activity of the resulting compounds at the cellular level and in animal models. Five pilot production sites have been established at the institute for pilot production of the developed products (hemosorbents, recombinant enzyme preparations, immunochemical reagents, oxyphytosterols, etc.).

The results of fundamental and applied research on methods and means for protecting plants from diseases, insects, weeds, and other adverse environmental factors that are safe for humans and the biosphere as a whole have formed the foundation for the development of new plant growth stimulants, pheromone compositions (codling moth LP-U and miller moth pheromones), active pesticide ingredients, and pesticide formulations (herbicides, insecticides, fungicides, etc.).

The institute's intellectual property currently consists of valid patents, laboratory process and pilot industrial regulations, technical specifications, and trademarks. License agreements are in place for the transfer of technologies for the production of immunodiagnostic products, hemosorbents, and pesticides to manufacturers.

The Institute of Bioorganic Chemistry is successfully developing international ties in its core research areas. The institute currently conducts joint research with research institutes in the CIS countries, Germany, the USA, Canada, Sweden, Finland, Denmark, the Netherlands, Vietnam, and other countries.

Official website of the Institute of Bioorganic Chemistry.