The Institute of Microbiology of the National Academy of Sciences of Belarus offers consumers probiotic bacterial preparation «Bilametrit» for prophylaxis and complex therapy of endometritis in cows under a manufacturing agreement and is looking for partners interested in a distribution services agreement.

The Institute of Microbiology of the National Academy of Sciences of Belarus together with EE «Grodno State Agrarian University» has developed probiotic bacterial preparation «Bilametrit» for prophylaxis and complex therapy of endometritis in cows.

The based of preparation is consortium of lactic acid bacteria Lactobacillus plantarum, L. rhamnosus, L. fermentum and Lactococcus lactis .
Number of viable cells in 1 gram - not less than 1.0x10¹⁰.

Principle of action:
Lactic acid bacteria suppress development of pathogenic and opportunistic microorganisms Staphylococcus, Streptococcus, Salmonella and Escherihia coli isolated from uterus exudate of newly calved cows suffering from postpartum endometritis. Owing to the enhanced adhesive activity they normalize microbial cenoses affected by antibiotic therapy.

Compatibility with other drugs: Constituent bacteria retain viability when applied in combination with antibiotics of cephalosporin, rifamycin, macrolide groups and iodinol in therapeutic doses.

«Bilametrit» will not cause and adverse effect on milk quality. Farm products may be consumed without restrictions following preparation treatment.

Preparation promotes to:
* prophylaxis and reduction by 50..92,5% of acute postpartum endometritis cases in newly calved stock;
* reducing duration of disease by 1.1 days.

Application guidelines:
«Bilametrit» powder before application is dissolved at dose 0,5 g per 100 ml of sterile saline and used within 24 h period.

For prophylaxis		For therapy
powder	foam-generating tablets	powder	foam-generating tablets
introduced into uterus of newly calved cows in 100 ml portions with 48..72 h intervals during 10 days	supplied into uterus of newly calved cows once at dose of 2 tablets	fed to newly calved cows intrauterinally at per diem dose 100 ml/head with 48 h intervals during 14 days	fed to newly calved cows intrauterinally at dose 2 tablets with 48 h intervals during 14 days

Package:
* polymeric bags lined with aluminium foil of 0.5 g, 5 g, 10 g, 25 g, 50 g, 100 g, 200 g weight;
* tablets are placed into vacuum polyethylene packets of 1, 2, 3, 4, or 5 pieces per each.

Terms of storage:
12 months since fabrication date within temperature range 0°C to +6°C. It is stored in dry shady place.

Application area: agriculture (animal husbandry, veterinary medicine).

Institute of Microbiology offers partners:
* probiotic bacterial preparation «Bilametrit» for prophylaxis and complex therapy of endometritis in cows under a manufacturing agreement;
* probiotic bacterial preparation «Bilametrit» for prophylaxis and complex therapy of endometritis in cows under a distribution services agreement.

Product catalog of the «Institute of Microbiology of NAS of Belarus» 2023, p.26.

Link on the Institute of Microbiology site (in Russian).

Import substitution of probiotic preparation «Giprolam» («Biotechagro» LLC, Russian Federation).

ТУ BY 100289066. 168-2022
Registration certificate dated 01.02.2023 № 8430-10-23

The Institute of Microbiology is the leading research center of the Republic of Belarus in the field of microbiology and biotechnology. The Institute's arsenal of innovative developments includes substances for medicines and diagnostics, biopreservatives, feed and food additives, biodisinfectants, probiotics, plant protection products, microbial fertilizers, wastewater and environmental treatment technologies that are in demand by the economy, and specific recommendations for combating biodamage.

Consumers interested in purchasing probiotic bacterial preparation «Bilametrit» for prophylaxis and complex therapy of endometritis in cows under a manufacturing agreement.

Partners interested in purchasing probiotic bacterial preparation «Bilametrit» for prophylaxis and complex therapy of endometritis in cows under a distribution services agreement.