The Institute of Biochemistry of Biologically Active Compounds offers consumers a multivitamin drug "Neurovasotropin" for the prevention of complications of diabetes (microangiopathy, neuropathy) under a manufactoring agreement and is looking for partners interested in a distribution services agreement.

The drug is intended for the prevention and correction of complications in patients with diabetes mellitus type 1 and 2. Antioxidant, anti-stress agent to reduce the degree of oxidative damage in diabetes (neuropathy, microangiopathy, nephropathy).

In connection with the important task of import substitution in the field of pharmaceuticals in the Republic of Belarus, an original drug has been developed for the prevention of complications in diabetes, which can be successfully produced in the country, replacing imported products (lipoic acid).

The pronounced antioxidant properties of thiamine and its derivatives have been revealed, which are used to develop a new drug "Neurovasotropin" based on lipoic acid, thiamine and pyridoxine. It has been established that pyridoxal phosphate to a lesser extent, and thiamine to a greater extent potentiate the antioxidant activity of lipoic acid. Inhibition of hydroxyl radical generation in the Fenton reaction by thiamine and thiochrome is a decisive argument in favor of their use with lipoic acid in oxidative stress. Thiamine is a more powerful antioxidant than lipoic acid in terms of its inhibitory effect on tyrosyl radicals of tyrosine.

Information is posted in the "Album of Promising Developments of Organizations of the National Academy of Sciences of Belarus for the Real Sector of the Economy" (2023), pp. 380-381. (in Russian)

The hypoglycemic, anti-stress, antioxidant effect of the drug was established on the model of alloxan diabetes in rats. The drug "Neurovasotropin" stabilizes the activity of the glutathione system, inhibits lipid peroxidation processes in rat tissues.

The developed complex has antioxidant, hypoglycemic effects, reduces the degree of glycotoxicity, and also an anti-stress effect, which is manifested in a decrease in the level of corticosterone. The introduction of the complex increases the survival rate of rats with alloxan diabetes by 2 times. The antioxidant effect of the developed complex significantly (more than 1.5 times) exceeds the effects of a well-known antioxidant agent used in diabetology - lipoic acid.

The developed product consists of a complex of biologically active substances used in pharmacology, their bioavailability is well studied. In pharmacological concentrations, they are safe.
The composition of the drug is innovative, there are no analogues. Additional studies to expand the application are possible.

Developed on the basis of the author's concept of hormonal mediation of the action of vitamins [Vinogradov, 1999], the new anti-stress complex "Neurovasotropin" is more effective in the prevention and correction of complications of diabetes mellitus (microangiopathy, neuropathy, nephropathy) than foreign analogues.

A finished dosage form of the drug "Neurovasotropin" and laboratory regulations have been developed. Preclinical studies have been conducted.

The effectiveness of the developed drug has been tested and confirmed in experimental models of aloxan diabetes on laboratory animals.

The following business model for cooperation is proposed - joint production, registration of a biologically active supplement, dosage form. Additional studies may be conducted to expand the indications for use.

An agent for the prevention of oxidative stress in diabetes: patent 21625 Republic of Belarus / V. V. Vinogradov, L. I. Nadnik, I. I. Stepuro [et al.]; date published: 28.02.2018.(in Russian)

The Institute of Biochemistry of Biologically Active Compounds is a leading scientific institution in the field of vitaminology, the study of molecular mechanisms of metabolism regulation in health and disease, the biochemistry of alcohol and drug addiction, neurochemistry and pharmacology.

The main areas of activity of the Institute:
- conducting fundamental and applied research aimed at studying the mechanisms of pathogenesis of liver diseases, cardiovascular and endocrine systems, alcohol addiction, pathological conditions associated with a deficiency of essential micronutrients and stress, in order to develop methods for their prevention, diagnosis and therapy;
- developing new innovative drugs, vitamin preparations, dietary supplements, as well as developing methods for isolating and purifying biologically active compounds from herbal medicinal raw materials, mastering their laboratory production for the needs of the pharmaceutical industry.

The Institute has developed unique technologies for obtaining dry extracts from medicinal plant materials and aromatic plants for use as components:
- in the production of dietary supplements,
- in the food industry,
- in the production of perfumes.

Custom production of products of deep processing and purification of extracts from plant raw materials for use as analytical standards is possible.

The Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus specializes in the development and production of diagnostic reagent kits for biochemical, hematological studies, reagent kits for the diagnosis of malignant neoplasms, infectious diseases, and the study of thyroid and reproductive functions.

The developed and manufactured kits allow obtaining consistently reproducible and accurate results at an affordable price. The company's strategy is aimed at innovative development. Reagent kits are used on semi-automatic and automatic laboratory systems, as well as in manual research. Adaptations for automatic analyzers can be provided additionally.

The Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus represents the world's leading manufacturers of reagents and materials in the Republic of Belarus, as well as its own products under the trademark "Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus".

The Institute’s mission is to meet the needs of scientists for high-quality reagents for scientific research at optimal prices in order to save budget funds.

Consumers interested in purchasing the multivitamin drug "Neurovasotropin" for the prevention of complications of diabetes (microangiopathy, neuropathy) under a manufacturing agreement.

Distributors interested in purchasing a multivitamin drug "Neurovasotropin" for the prevention of complications of diabetes (microangiopathy, neuropathy) under a distribution services agreement.