The Institute of Physical Organic Chemistry offers consumers a source of flavonoid compounds contained in an aqueous solution of propolis, the biologically active food supplement "Niko-Propoletin," under a manufacturing agreement and/or licensing agreement, and is looking for partners to conclude a distribution services agreement.

Flavonoid compounds contained in aqueous propolis solutions are widely used in dietary supplements (DS) due to their antioxidant, anti-inflammatory, and immunomodulatory properties. These supplements are used to strengthen the immune system, prevent disease, and improve overall well-being.

Major global manufacturers of propolis-based dietary supplements:

1. Apis Flora (Brazil)
- Features: One of the leading manufacturers of propolis-based products, including aqueous solutions rich in flavonoids.
2. Comvita (New Zealand)
- Features: Manufacturer of natural products, including propolis supplements with high flavonoid content.
3. Bee Health (UK)
- Features: The company produces a wide range of propolis products, including aqueous extracts.
4. Apis Global (USA)
- Features: Manufacturer of propolis-based dietary supplements, including products with flavonoid compounds.
5.
S. Eco Bee Farms (USA)
- Features: The company specializes in organic bee products, including aqueous propolis extracts.
6. Herbaland Naturals (Canada)
- Features: Manufacturer of natural supplements, including propolis products with flavonoid compounds.
7. Propolia (France)
- Features: French manufacturer of propolis products, including aqueous solutions for health promotion.

The biologically active food supplement "NIKA PROPOLETIN," developed at the Institute of Physical Organic Chemistry, is a source of flavonoid compounds found in aqueous propolis solutions:
flavonols, represented by mono- and dimethyl esters of kaempferol; flavones, including apigenin and chrysin.
The dietary supplement "NIKA PROPOLETIN" has a preventative and restorative effect; it compensates for the deficiency of vital biologically active components. The biological action of the dietary supplement "NIKA PROPOLETIN" is due to its biologically active ingredients:
- Kaempferol – has pronounced anti-inflammatory, antitumor, antimicrobial, antihistamine, and cardioprotective effects. As an antioxidant, it protects cells from free radical damage and prevents aging. Kaempferol inhibits fatty acid synthesis in malignant cancer cells, reducing the risk of developing cancer. In particular, regular use of kaempferol in its natural form, in the form of extracts and dietary supplements, can serve as an effective preventative measure against lung and reproductive system cancer.
- Apigenin – has a general protective function, primarily exerting a neuroprotective effect and inhibiting tumor growth. Preclinical and clinical studies have confirmed its anxiolytic, antidepressant, and sedative effects. Apigenin helps prevent Alzheimer's disease and memory problems; it also has antidiabetic and antimicrobial properties. Chrysin is a natural antioxidant with antitumor, cardioprotective, hepatoprotective, nephroprotective, hypoglycemic, antihyperlipidemic, antidepressant, antiallergic, and anxiolytic effects.

This information is published in the Catalog "100 Best Developments of the National Academy of Sciences of Belarus for the National Economy in 2022–2023," pp. 126–127, and the Catalog "Advanced Developments of the National Academy of Sciences of Belarus" 2024, pp. 144–145.

The NIKA PROPOLETIN dietary supplement is produced using domestic raw materials and an original ultrasound technology.

The scientific and technical level is world-class.

Readiness for production:

The "Nika Propoletin" biologically active food supplement has been developed and registered with the Belarusian State Institute of Standardization and Inspection (TU BY 100185198.211-2021).
State Registration Certificate BY.70.06.003.R.01.002920.11.232 was received on November 2, 2023.
Serial batches of the product have been manufactured in accordance with the Consolidated Test Protocol of the Federal Research Center of Nutrition and Biotechnology dated August 2, 2023, No. 5225/0363/14-23.

Initiative development of the Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus in the period 2021–2023.

The Institute of Physical Organic Chemistry is a global leader in the development, production, and use of ion-exchange fibrous materials and artificial substrates for plant cultivation. The Institute's work in membranes and membrane technologies is widely recognized. It has developed and manufactured membrane materials for ultra- and microfiltration in the form of continuous webs and capillaries, cassette, roll, and hollow fiber elements for use in the energy, food, pharmaceutical, electronics, and other industries.

The Institute's scientists have discovered and studied the following reactions: heterocyclization of azomethines with carbonyl compounds, hydroamination of oxygen-containing compounds, initiated decarboxylation of mercury acylates, and the construction of an isothiazole ring from 2-nitropentachlorobutadiene and sulfur. Convenient methods for synthesizing benzoquinolines, amines, pyridines, and organomercury compounds have been developed, as well as electrochemical methods for producing p-complexes of transition metals, and methods for synthesizing a variety of functionally substituted organohalogen compounds, carboranes, and peroxides.

Catalysts developed at the Institute have been implemented at major chemical plants. An antiblock composition preventing cellophane film from sticking together during production has been implemented industry-wide. An industrial radiation-chemical technology for producing the blood plasma substitutes "Rondex" and "Neorondex" has been developed.

The Institute's activities are aimed at developing scientific principles and technologies for creating new polymeric materials with special properties (selectively permeable, sorption, ion-exchange, and catalytically active) for use in industry, ecology, agriculture, and water treatment. The development of synthesis methods and technologies for producing medicinal substances based on amino acids and their derivatives, biologically active substances and compositions for medicine and agriculture, and functionally substituted organic and organoelement compounds.

The Institute conducts international scientific and technical cooperation through direct agreements with scientific institutions in Russia, Ukraine, Germany, Poland, Sweden, China, and elsewhere. Much attention is paid to fulfilling contracts for research and development and the manufacture of high-tech commercial products based on its own developments with organizations and firms in Saudi Arabia, Germany, Korea, Russia, and the United States.

Official website of the Institute of Physical and Organic Chemistry of the National Academy of Sciences of Belarus.

Consumers interested in purchasing the source of flavonoid compounds contained in the aqueous propolis solution, the biologically active food supplement "Niko-Propoletin," under a manufacturing agreement and/or licensing agreement.

Partners interested in purchasing the source of flavonoid compounds contained in the aqueous propolis solution, the biologically active food supplement "Niko-Propoletin," under a distribution services agreement.